Does cleroderma affect fingernails2/7/2024 ![]() A number of different influences seem to be involved. Systemic sclerosis may be triggered by certain germs (such as viruses), medicines, street drugs and chemicals. Systemic sclerosis is more common in people who have a family member with systemic sclerosis. There is probably an inherited tendency to develop it. It is not known what triggers the immune system to cause systemic sclerosis. So, systemic sclerosis is also classed as a connective tissue disease. Your connective tissue supports, binds or separates other tissues and organs within your body and can also be a kind of packing tissue in your body. In systemic sclerosis, the immune system damages the connective tissue cells, which are found in many parts of the body. In autoimmune diseases the body makes similar antibodies (autoantibodies) that attack its normal cells. These antibodies help to kill the germs causing the infection. Normally, our body makes proteins called antibodies to fight infections - for example, when we catch a cold or have a sore throat. This means that the immune system causes damage to some of the body's own cells. Systemic sclerosis is an autoimmune disease.
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